PRS4 Burden of Hospitalizations in Patients with Chronic Rhinosinusitis (CRS) with and without Nasal Polyps: A Propensity Score Matched Analysis of In-Patient Claims Database

Abstract

To analyze trends in hospital length of stay, total costs and comorbidities in patients with Chronic rhinosinusitis (CRS) with and without Nasal Polyps (CRSwNP and CRSsNP). The 2016 National Inpatient Sample (NIS) data set from the Healthcare Cost and Utilization Project was utilized in order to determine the number of hospital admissions for Chronic rhinosinusitis (CRS) with and without Nasal Polyps (CRSwNP and CRSsNP). Propensity score matched analysis was conducted to compare hospital LOS and costs in selected patients. Thirty comorbidities were assessed using Elixhauser scoring. Multivariate logistic regression was conducted to assess predictor variables for LOS and costs. In 2016, there were an estimated 159035 hospitalizations with a diagnosis of Chronic rhinosinusitis (CRS), of which 3.7% had CRSwNP. The mean age was similar for patients with CRSsNP and CRSwNP 56.34 (SD 21.73) and 52.44 (SD 22.55) years, respectively. Approximately 58% and 45% of CRSwNP and CRSsNP were male, respectively. The mean LOS and total hospital charges were similar for CRSsNP and CRSwNP. 5.82 (SD 8.34) and 5.49 (SD 5.77) years, and $62789 and $64468, respectively. Compared to CRSsNP, CRSwNP had a relatively higher rate of Chronic Pulmonary Disease (47% vs 38%). Other top comorbidities in CRSsNP and CRSwNP were: Hypertension (42%), Cardiac Arrhythmias (21%) and Depression (18%). Relatively higher percentage of CRSsNP admissions were associated with an Emergency Department (ED) visit, as compared to CRSwNP (66% vs 57%). Chronic rhinosinusitis (CRS) with and without Nasal Polyps (CRSwNP and CRSsNP) poses significant burden on the healthcare system due to high rate of hospitalizations and long LOS. There is a need for better management of CRS patients.