PRS12 ALIGNING COPD OUTCOMES WITH PATIENT-INFORMED VALUE ELEMENT DOMAINS FOR USE IN ECONOMIC EVALUATIONS

Abstract

One approach to incorporate patient-informed value elements in economic evaluations is to use stated preference methods to derive quantitative results about patients’ preferences. Our ongoing work aims to elicit the value elements in healthcare decision-making that are important to the patient community by directly engaging patients. The objective of this study was to align chronic obstructive pulmonary disease (COPD) outcomes and value attributes identified in the literature with the patient-informed value element domains our group derived directly from patients. We searched PubMed and EMBASE to identify literature about COPD patient preferences measured using discrete choice experiments, conjoint analysis and other stated preference methods. We identified a set of unique attributes related to outcomes, patient values, and preference for COPD treatment from the literature. Three independent reviewers mapped each COPD-specific attribute onto one of 47 patient-informed value elements, which were nested within the 11 domains we derived from our previous research. We retrieved 20 unique studies of COPD patient preferences. We extracted 56 COPD attributes from these studies. These attributes aligned with 6 of the 11 patient-informed value element domains: disease burden, accessibility of care/treatment, cost incurred by the patient, personal well-being, social well-being and tolerability. COPD attributes from the literature did not align with the following categories of patient-informed value elements: personal values, stigma, cost incurred by the family, forecasting and healthcare service delivery. This work illustrates how COPD outcomes reported in the literature align with patient-informed value element domains. In order to make value assessments more representative of patient values, future research should address the challenge of how to incorporate patient-informed value elements in economic evaluations.