PRP and PRF-Subgroups and Divisions When Used in Dentistry.

Paulina Pietruszka,Irena Duś-Ilnicka,Anna Paradowska-Stolarz,Izabela Chruścicka

doi:10.3390/jpm11100944

Paulina Pietruszka, Irena Duś-Ilnicka + Show 2 more

Open Access

https://doi.org/10.3390/jpm11100944

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Journal: Journal of Personalized Medicine	Publication Date: Sep 23, 2021
Citations: 33	License type: CC BY 4.0

Affiliation: Wroclaw Medical University

Abstract

Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

Highlights

Introduction to platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) SubgroupDivisionsThe regenerative potential that platelets provide in regenerative medicine was rapidly examined but their usage in oral and maxillofacial surgery was only approved in the late 1990s [1]
The aim of this article was to show the possibilities of using PRP and PRF as a scaffold in the process of tissue regeneration, treatment of intrabony defects and regenerative endodontic treatment
Leukocyte- and platelet-rich fibrin (L-PRF) and the associated blood clot are more homogeneous and fibrous compared with the gelatinous Leukocyte- and platelet-rich plasma (L-PRP)

Summary

Introduction

Introduction to PRP and PRF SubgroupDivisionsThe regenerative potential that platelets provide in regenerative medicine was rapidly examined but their usage in oral and maxillofacial surgery was only approved in the late 1990s [1]. Platelets play a key role in the immune system [1,2,3]. Platelets release special proteins that have the capacity to inhibit bacteria and fungi activity, e.g., platelet growth factor (PDGF), transforming growth factor (TGF-β) and insulin-like growth factor (IGF-I) [1,4,5] These factors support biological processes that are necessary for proper healing and regeneration [2,4]. Platelets take part in the recognition and neutralization of pathogenic organisms. They recruit leukocytes to sites of infection and inflammation and modulate their functions [1,4]

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