Proximity of chromatin to the nuclear envelope, does not, by itself, affect gene expression in drosophila

Abstract

Multiple studies have shown a correlation between gene expression and positioning of the genes at nuclear lamina which lines nuclear envelope (NE). However, the exact relationship between proximity to NE and reduced gene expression is still unclear. Here, we ask whether there is a causal connection between noticeable changes in gene expression level in Drosophila nuclei and frequency of localization at the NE of the groups of genes in topologically associating domains (TADs) of Drosophila nuclei.