Abstract
In previous studies it was documented that proximal tubule sodium reabsorption capability was preserved in healthy elderly, while Thick Ascending Loop of Henle (TALH) one was reduced. Aim: Since, it has also been documented that senile changes are accelerated in HIV patients, we performed a prospective study in order to evaluate if there was a significant difference in proximal and TALH function between healthy elderly and HIV patients. Methods: Proximal and TALH was analyzed by performing hyposaline infusion test in 10 young (≥ 18-≤ 40 years old) HIV volunteers under treatment with tenofovir, free of viral charge, and normal renal function: serum creatinine, urinary sediment, and renal ultrasound), with the control group made up of 10 healthy old volunteers (≥ 65 years old). Results: During the test, it was observed that the HIV group had a significant reduction of natremia (HIV: 133 ± 1 mmol/l vs. healthy elderly: 139 ± 1 mmol/l, p=0.03), serum osmolarity (HIV: 276 ± 4 mOsm/l vs. elderly: 288 ± 3 mOsm/l, p=0.03) and free water clearance (HIV: 3.5 ± 3 ml/min/1.73 m² vs. elderly: 5 ± 8 ml/min/1.73 m², p ≤ 0.01). Besides, HIV patients showed an inadequate and significant increase in their urinary tonicity in comparison with the healthy elderly group: HIV: 170 ± 18 mOsm/l vs. elderly: 90 ± 10, p ≤ 0.01. Regarding proximal tubular function, it was found that it was preserved in both groups. Conclusion: Proximal tubule sodium reabsorption was normal, while free water clearance was significantly reduced in young HIV patients in comparison with healthy elderly volunteers.
Highlights
In previous studies it was documented that proximal tubule sodium reabsorption capability was preserved in healthy elderly, while thick ascending loop of Henle (TALH) one was reduced in this population [1,2]
In this study proximal and TALH tubular functions were studied in 20 Caucasian males volunteers which had similar weight, and normal basal serum sodium, osmolarity, and creatinine values (Table 1)
It was documented that serum sodium (SNa), and Serum Osmolarity (SO) were significantly reduced during hyposaline infusion test in HIV patients compared to healthy old (O) volunteers: SNa 133 ± 1 mmol/l (HIV) vs 139 ± 1 mmol/l (O), p=0.03; SO: 276 ± 4 mOsm/l (HIV) vs 288 ± 3 (O), p=0.03 (Table 2)
Summary
In previous studies it was documented that proximal tubule sodium reabsorption capability was preserved in healthy elderly, while thick ascending loop of Henle (TALH) one was reduced in this population [1,2]. These evaluations were performed by applying a validated and specific physiological test for that, the hyposaline infusion test [3]. We performed a prospective study in order to evaluate, applying the hyposaline infusion test, if there was a significant functional difference in the above mentioned renal tubular segments between these two populations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
