Abstract

BackgroundThe optimal management of gastric variceal bleeding in patients with non-cirrhotic portal hypertension (NCPH) is debatable due to the lack of data from large randomized controlled trials. Here we present our experience on proximal splenorenal shunt (PSRS) surgery in NCPH patients with bleeding gastric varices.MethodsOver a five-year period, a total of 25 PSRS surgeries were performed and data was collected prospectively. Nineteen extrahepatic portal vein obstruction (EHPVO) and six non-cirrhotic portal fibrosis (NCPF) patients with bleeding fundic or isolated gastric varices and normal liver function were included. The collected data was analyzed retrospectively.ResultsOf the 25 patients who underwent PSRS five were lost to follow-up. Twenty patients (80%) were followed up for a median of 3.4 (1-5) years. Gastric variceal regression was noted in all 20 patients with the disappearance of varices in eight patients. On follow-up, shunt thrombosis was noted in four (20%) patients of whom, two had rebleeding between six months and three years after shunt surgery.ConclusionPSRS was effective in controlling gastric variceal hemorrhage in 92% (23 of 25) of patients with preserved liver function.

Highlights

  • The optimal management of gastric variceal bleeding in patients with non-cirrhotic portal hypertension (NCPH) is debatable due to the lack of data from large randomized controlled trials

  • Gastric variceal regression was noted in all 20 patients with the disappearance of varices in eight patients

  • Non-cirrhotic portal hypertension (NCPH) refers to portal hypertension caused by two vascular diseases of the liver: extrahepatic portal venous obstruction (EHPVO) and non-cirrhotic portal fibrosis (NCPF)

Read more

Summary

Introduction

Non-cirrhotic portal hypertension (NCPH) refers to portal hypertension caused by two vascular diseases of the liver: extrahepatic portal venous obstruction (EHPVO) and non-cirrhotic portal fibrosis (NCPF). The management of gastric varices (GVs) is still evolving [2,3]. The present evidence favors the use of cyanoacrylate glue as first-line therapy for both acute bleeding and secondary prophylactic eradication of gastric varices [4,5]. Most of the available literature in the management of gastric varices is on cirrhotic patients. The access to balloon-occluded retrograde transvenous obliteration (BRTO) or transjugular intrahepatic portosystemic shunts (TIPS) for the treatment of gastric varices is often limited in countries with constrained resources [8]. The optimal management of gastric variceal bleeding in patients with non-cirrhotic portal hypertension (NCPH) is debatable due to the lack of data from large randomized controlled trials. We present our experience on proximal splenorenal shunt (PSRS) surgery in NCPH patients with bleeding gastric varices

Methods
Discussion
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call