Abstract
Introduction: The current American Joint Committee on Cancer (AJCC) staging system for proximal cholangiocarcinoma may be inaccurate as the bile duct lacks discrete tissue boundaries. The objective of the current study was to examine the accuracy of the AJCC staging system for proximal cholangiocarcinoma. In turn, we sought to determine whether depth of tumor invasion was a more accurate predictor of prognosis in patients with resected proximal cholangiocarcinoma. Methods: Between 1987 and 2004, 297 patients who underwent surgical resection of cholangiocarcinoma were identified from a prospective, single-institution hepato-pancreato-biliary database.
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