Abstract
Purpose: Voltage-gated sodium channels (NaV) are responsible for the electrochemical transmission of nerve signals. The cation channels NaV1.7, NaV1.8, and NaV1.9 are principally expressed on nociceptors making them attractive targets for pain control. Small molecule antagonists directed against NaV1.7 have been found to be effective at reducing osteoarthritis (OA) pain centrally; however, the role of this ion channel peripherally is less clear. Moreover, the analgesic effect of these antagonists is short-lived.
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