Prototyping sutureless shape-memory valve stent via integrated 3D printing

Abstract

Abstract Transcatheter aortic valve replacement (TAVR) has increasingly emerged as a forefront option for treating aortic valve diseases. However, the currently prevalent valve prostheses used in TAVR typically involve stitching biologic leaflets onto metallic stents, which introduces challenges in the durability of leaflets and the biocompatibility of metallic stents. This work proposes an integrated additive manufacturing method for prototyping sutureless prosthetic aortic valves that combine shape memory polymer (SMP) stent and hydrogel valve leaflets. The SMP stent exhibits sufficient toughness to maintain structural integrity upon shape memory programming, while the Fe3+-treated hydrogel leaflets possess sufficient swelling resistance to ensure dimensional stability. Finally, the proof-of-concept valve stent is successfully fabricated by integrated 3D printing and validated via an in vitro hemodynamic experiment. Overall, our approach holds promise for prototyping sutureless polymeric valve stents for future generations.