Prototyped flexible grafting tray for reconstruction of mandibular defects

Abstract

In our previous studies, prototyped individual bone-grafting trays have been used to restore discontinuous mandibular defects. However, the attempts have shown that the trays have shielded the graft from stress, which caused considerable resorption of bone. To eliminate the shielding, we designed a flexible tray. Finite element analysis was used to compare the distribution of strain on the bone grafts that were placed in flexible and conventional trays. The analogue computation suggested that most of the strain on the graft in the flexible tray resulted in a beneficial mechanical environment, while in the conventional tray more than half of graft was in the lowest class of strain (disuse – <50μstrains). Animal experiments were conducted on hybrid dogs, and the prototype flexible tray was used to carry particles of autologous cancellous iliac bone to reconstruct a 40mm defect in the mandibular body. Sequential radionuclide bone imaging was used to monitor the bone metabolism. Animals were killed at 4, 12 and 24 weeks, and specimens processed for quantitative histological examination. The data from the flexible trays were compared with those from the conventional trays, as in our previous study. The results showed that bone metabolism was more active in the flexible tray than in the conventional tray during the early stages. There was increased bony adaptation in the flexible tray. These results indicate that the flexible tray can efficiently eliminate the shielding from stress, and allow more occlusive force to be conducted on to the bone graft, which results in better remodelling of the graft.