Abstract
This report presents a transdermal methotrexate (MTX) delivery system prototype using a bacterial cellulose (BC) matrix with microneedles (MN). The MTX-loaded BC layer (BC/MTX) was incorporated in microneedles. The BC/MTX/MN system was evaluated for structure, mechanical properties, cytotoxicity and in vitro drug release. After 24 h, 73% of MTX was released from BC. Cytotoxicity results showed 123% cell viability for BC and 111% for BC/MTX. These findings suggest the potential of the delivery system for releasing MTX in the treatment of dermatological diseases.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
