Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter

C.S Temple,C.A.R Boyd

doi:10.1016/s0005-2736(98)00093-5

Proton-coupled oligopeptide transport by rat renal cortical brush border membrane vesicles: a functional analysis using ACE inhibitors to determine the isoform of the transporter

C.S Temple, C.A.R Boyd

https://doi.org/10.1016/s0005-2736(98)00093-5

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Journal: BBA - Biomembranes	Publication Date: Aug 1, 1998
Citations: 31	License type: elsevier-specific: oa user license

Affiliation: University of Oxford

#Rat Renal Cortical Brush Border #Cortical Brush Border Membrane Vesicles + Show 8 more

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Abstract

We demonstrate that the angiotensin-converting enzyme inhibitors enalapril and captopril inhibit the transport of D-Phe-L-Gln into PepT1-expressing Xenopus oocytes and into rat renal cortical brush border membrane vesicles (BBMV). The kinetics of inhibition are competitive. Enalapril and captopril are not substrates for PepT2 (Boll et al., Proc. Natl. Acad. Sci. 93 (1996) 284–289). Therefore we conclude that in rat renal cortical BBMV this neutral dipeptide is transported via PepT1.

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