Protonation and Metal Complex Formation of Phosphorus Containing Acids and Bases

Abstract

Biorelevant acylphosphonic acids, phosphonocarboxylic acids, aminophosphonic acids and corresponding phosphinic acids give rise to interesting protonation and metal complex formation equilibria. Macroscopic stability constants are obtained by high precision PC-guided titration followed by iterative data evaluation. Additional informations on dynamically averaged structures of species involved in macroscopic equilibria, e. g. ion specific chemical shifts and coupling constants, are accessible via NMR-controlled titrations.