Abstract

Of 49 patients, 43 had prior surgery, 23 with close/positive margins. Six patients had biopsy only. Skull-base invasion was noted in 34 of 49 patients, (69%). Ages ranged from 16 to 82 years with a median of 58 years. Histology included sino-nasal undifferentiated carcinoma, adenoid cystic carcinoma, esthesioneuroblastoma, mucosal melanoma, spindle-cell carcinoma and osteogenic sarcoma. Prescribed doses ranged from 64.8 GyE to 69.6 GyE for post-op negative margins, to 74.4 GyE for presence of positive margins or presence of gross unresectable tumor at 1.2 GyE twice-a-day. Proton treatments were delivered with orthogonal kV x-ray imaging guidance to achieve 1 mm setup accuracy for each fraction.

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