Proton Therapy for Ocular Melanoma: A Dosimetric Comparison of Three Different Delivery Systems

Abstract

The purpose of this study is to compare the treatment plans for intraocular tumors with two types of Pencil Beam Scanning (PBS) machine configurations and compare them with the widely used uniform scanning (US)/scattering technique. Two virtual PBS machines were constructed for ocular planning. The first machine (P1) consisted of a standard spot size and a 7.5cm WET range shifter (RS) positioned 50cm upstream from the aperture. The second machine (P2) had a smaller spot size and used a 4cm WET RS but had no aperture support. These PBS delivery systems resemble currently available models. Ten patients with different locations and sizes of intraocular tumors were planned with US using 2-3 conformal fields following our institution's intraocular criteria. PBS spot patterns for each machine were optimized using the same beam geometry as the US plan to achieve identical tumor coverage. PBS distribution was calculated using Monte Carlo. All air gaps were minimized as small as clinically achievable. PBS plans passed robustness criteria with all scenarios meeting CTV D95>95% with 2mm translational offsets and 3.5% range uncertainty. The average conformity index (CI) of 95% reference isodose was better for both PBS techniques (P1: 1.43±0.22, P2:1.5±0.32) versus US (1.72±0.56) for all plans (p = 0.025, p = 0.034). The average CI of 50% reference isodose was worse for the P2 plans (10.4±3.3) compared to US (9.34±2.93). However, CI 50% for P1 plans was better than US (5.21±1.24, p<0.003). There were no significant improvements to OARs using P2. However, the mean dose to anterior structures ciliary body, lacrimal gland, and D0.03cc lens were significantly lower in the P1 plans than in the US plans (p<0.016). Small spot size PBS systems without apertures can achieve similar coverage to US plans but have higher OAR dose. PBS systems with a standard spot size and reconfigured RS and apertures are better for anterior OAR sparing and is non-inferior to US planning of intraocular targets.