Abstract
Objective Systematically evaluate for curative effect and economical evaluation of treating gastroes ophageal refulx disease(GERD) by proton pump inhibitors(PPI) and Laparos copic antireflux surgery(LARS). Methods Collecting RCT of treating GERD by PPI and LARS via computer retrieval in CNKI(1944 to 2014.12), Wanfang Database(1994 to 2014.12), Embase Database(1995 to 2014.12), Pubmed Database(1994 to 2014.12)and Cochrane Center Database of Controlled Trial(2005 to 2014.12). Carry on Meta-Analysis by software RevMan5.3 of Cochrane Library. Results 13 purpose literatures are incorporated totally.Including 3 623 cases, PPI group(control group)1830 cases and LARS group(experiment group)1 793 cases.Among which there are 8 literatures of evaluation A-Level and 5 literatures of evaluation B-Level.The final result of Meta-Analysis shows that on the aspect of post treatment untoward effect and Gastrointestinal symptom rating scale and Quality of life general well-being index, there are no statistical differences between LARS group and PPI group when treating GERD.The odds ratios(RO)are 5.00(95% CI is 0.69~36.09, P=0.11)and-0.20(95% CI is 0.65~0.26, P=0.40)and 0.55(95% CI is 0.09~1.18, P=0.09)respectively.While there exist statistical differences on the aspect of Economic Evaluation 1 year and failure after treatment.The ORs are 1.89(95% Cl is 0.24~3.53, P=0.02)and 1.61(95% Cl is 1.06~2.42, P=0.02)respectively. Conclusion There is no obviously statistical difference of gastrointestinal symptom rating and untoward effect after treatment and quality of life general well-being index indicates of GERD via LARS and PPI, which means that there is no more advantages of PPI than LARS on treating GRED.The statistical difference appears in economic evaluation and treatment failure. Key words: Gastroesophageal refulx disease; Proton pump inhi bitors; Laparoscopil antireflux sugery; Meta-analysis
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