Abstract
Inhibition of gastric acid secretion is necessary to treat many gastrointestinal diseases. Proton Pump Inhibitors (PPIs) are very effective drugs, used for gastric acid inhibition and therapy of important erosive and non-erosive gastrointestinal disorders in animals as well as humans. In this review, general properties of PPIs, their mode of action, pharmacokinetics, efficacy, adverse effects, drug interactions and clinical and alternative uses in veterinary medicine were evaluated.
Highlights
Gastric acid is the secretion of parietal cells of stomach and it is controlled by paracrine, endocrine and neuronal systems
Pump Inhibitors (PPIs) are widely used for treatment of many erosive and non-erosive gastrointestinal disorders, such as peptic ulcers, Gastro-Oesophageal Reflux Disease (GERD), Barrett’s oesophagus, ZollingerEllison syndrome, dyspepsia and Helicobacter pylori infection in humans and different animal species (Shin and Sachs, 2004; 2008; Papich, 2009)
Since PPIs are metabolized by hepatic CYPs, they may interfere with many drugs
Summary
Gastric acid is the secretion of parietal cells of stomach and it is controlled by paracrine, endocrine and neuronal systems. H+/K+ ATPase, is the main actor to pump hydrogen ions into the stomach lumen (H+/K+ proton pump) (Shin and Sachs, 2008; Hori et al, 2011; Garcia-Mazcorro et al, 2012). The Proton Pump Inhibitors (PPIs) provide an irreversible inhibition of the gastric pump in parietal cells (Papich, 2009; Kosma et al, 2016). Thanks to this effect, PPIs are widely used for treatment of many erosive and non-erosive gastrointestinal disorders, such as peptic ulcers, Gastro-Oesophageal Reflux Disease (GERD), Barrett’s oesophagus, ZollingerEllison syndrome, dyspepsia and Helicobacter pylori infection in humans and different animal species (Shin and Sachs, 2004; 2008; Papich, 2009).
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