Abstract
Abstract This study aimed to explore the relationship between proton pump inhibitors (PPIs) and gastric tumors and determine the reasons behind these connections. We reviewed studies on PPIs and stomach tumors. We explored the relationship between PPIs and different types of gastric neoplasms according to the classification of gastric neoplasms. Long-term use of PPIs is associated with stomach infection, high gastrin levels, and rebound acid hypersecretion, which are directly or indirectly related to the development of gastric neoplasms. PPIs can increase the risk of gastric fundal polyps. Further evidence is needed to prove that it can increase the risk of gastric cancer.
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