Abstract
Increased bodily CO2 concentration alters cellular pH as well as sleep. The proton pump, which plays an important role in the homeostatic regulation of cellular pH, therefore, may modulate sleep. We investigated the effects of the proton pump inhibitor “lansoprazole” on sleep-wakefulness. Male Wistar rats were surgically prepared for chronic polysomnographic recordings. Two different doses of lansoprazole (low: 1 mg/kg; high: 10 mg/kg) were injected intraperitoneally in the same animal (n = 7) and sleep-wakefulness was recorded for 6 hrs. The changes in sleep-wakefulness were compared statistically. Percent REM sleep amount in the vehicle and lansoprazole low dose groups was 9.26 ± 1.03 and 9.09 ± 0.54, respectively, which increased significantly in the lansoprazole high dose group by 31.75% (from vehicle) and 34.21% (from low dose). Also, REM sleep episode numbers significantly increased in lansoprazole high dose group. Further, the sodium-hydrogen exchanger blocker “amiloride” (10 mg/kg; i.p.) (n = 5) did not alter sleep-wake architecture. Our results suggest that the proton pump plays an important role in REM sleep modulation and supports our view that REM sleep might act as a sentinel to help maintain normal CO2 level for unperturbed sleep.
Highlights
The proton pump helps in performing several important cellular functions including the homeostatic regulation of cellular pH and acidification of intracellular organelles [1]
It plays a critical role in the acid-base balance [2, 3] and its altered activity is associated with the development of pathophysiological conditions such as gastroesophageal reflex disease (GERD), increased osteoclast activity, increased amyloid beta production in the brain, reduction in brain acetylcholinesterase activity, and alteration in spatial and chromatic visual perception [4,5,6,7,8,9,10,11]
rapid eye movement (REM) sleep amount compared to the vehicle and low dose of lansoprazole (P < 0.01; F(3,27) = 6.53)
Summary
The proton pump helps in performing several important cellular functions including the homeostatic regulation of cellular pH and acidification of intracellular organelles [1]. It plays a critical role in the acid-base balance [2, 3] and its altered activity is associated with the development of pathophysiological conditions such as gastroesophageal reflex disease (GERD), increased osteoclast activity, increased amyloid beta production in the brain, reduction in brain acetylcholinesterase activity, and alteration in spatial and chromatic visual perception [4,5,6,7,8,9,10,11]. The two sleep stages: nonrapid eye movement (NREM) and rapid eye movement (REM)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
