Abstract
Proton nuclear magnetic resonance relaxation times, T 1 and T 2, of water in unfixed gray and white matter from normal and edematous rabbit brain tissues were measured in vitro at 23°C and 100 MHz to evaluate the effects of the temperature (−25°C to 37°C) and duration (0 to 96 h) of tissue storage on relaxation times. T 1 and T 2 tended to decrease during storage, probably from slow dehydration of the tissue. This effect was greatest in tissues stored at 37°C and least in those stored at 4 and −25°C; decreases in T 1 and T 2 were greater in white matter than in gray matter. Freezing brain tissue to −25°C caused a sudden decrease in the T 2 of normal white matter. Relaxation times were constant for 5 h in tissues stored at 23°C and for 40 h at 4°C. These results correlated well with corresponding tissue water loss.
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