Abstract
AbstractAbstract: Proton beam therapy is a conservative treatment of choroidal melanoma. This study reports our results in terms of overall survival, metastasis‐free survival and secondary enucleation in 3404 patients We present a retrospective, single‐center study of patients treated for choroidal melanoma with proton beam therapy between January 1992 and December 2010 (total dose of 60 cobalt Grays equivalent delivered in 4 fractions over 4 days). The initial clinical tumor characteristics, treatment and follow‐up were recorded prospectively. Overall survival, metastasis‐free survival and enucleation free survival and their prognostic factors were statistically analyzed. 3404 patients were included during this period. The median follow‐up was 98 months. The overall survival rate, metastasis‐free survival rate, local recurrence and secondary enucleation at 5 years were respectively 64%, 74%, 3.82%, 6.79%. The prognostic factors for metastasis‐free survival: the location, the diameter and tumor thickness, and cytogenetic factors body. Risk factors of secondary enucleation are essentially tumor size (diameter, thickness and TNM). Treatment with proton therapy provides excellent local control of choroidal melanoma.
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