Abstract
The pH dependence of oxygen-17 N.M.R. linewidths has been measured in H2O, D2O, and an aqueous solution of lysine. In each case, the line is significantly broadened in the region of neutrality as a result of the reduction in the rate of proton transfer which leads to incomplete averaging of the splitting of the 17O multiplet. The modified Bloch equations for exchange between lines of the proton-coupled triplet of H2O and the quintet of D2O have been solved and used to fit the experimental data to provide a direct measure of the rate constants for acid- and base-catalysis. The results show approximate agreement with estimates of the isotope effect based on ionic mobilities and indicate that the amino acid has a significant catalytic effect.
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