Protocols for Oligonucleotides and Analogs; Synthesis and Properties: Edited by S. Agrawal. 502 pp. 1993. Humana Press, New Jersey. PB.$59.50

Abstract

A Brief History of Oligonucleotide Synthesis. Oligonucleotide Synthesis: Phosphotriester Approach. Oligodeoxyribonucleotide Synthesis: Phosphoramidite Approach. Oligodeoxynucleotide Synthesis: H-Phosphonate Approach. Oligoribonucleotide Synthesis: The Silyl-Phosphoramidite Method. Synthesis of 2'-O-Alkyloligoribonucleotides. An Improved Method for the Synthesis and Deprotection of Methylphosphonate Oligonucleotides. Oligonucleotide Phosphorothioates. Synthesis and Purification of Phosphorodithioate DNA. Oligodeoxyribonucleotide Phosphotriesters. Oligonucleotide Boranophosphate (Borane Phosphate). Oligonucleotide Phosphorofluoridates and Fluoridates. a-Oligonucleotides. Stereospecific Synthesis of P-Chiral Analogs of Oligonucleotides. Oligonucleotide Analogs with Dimethyl-Sulfide, -Sulfoxide, and -Sulfone Groups Replacing Phosphodiester Linkages. Oligonucleotide Analogs Containing Dephosphointernucleoside Linkages. Scaleup of Oligonucleotide Synthesis: Solution Phase. Large Scale Oligonucleotide Synthesis Using Solid Phase Approach. Solid-Phase Supports in Oligonucleotide Synthesis. Index.