Abstract
The treatment of panhypopituitarism involves the hormone replacement of each deficiency diagnosed in the patient with pituitary or hypothalamic pathology. In corticotropin deficiency (ACTH), thyrotropin (TSH) and gonadotropins (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]) replacement therapy consists of hormone replacement of the target organs; treatment with pituitary hormones is only indicated for fertility induction and growth hormone (GH) deficiency. In a multiple hormonal deficit, the order of therapeutic replacement is of vital importance: first corticotrope axis, followed by the thyroid and later the gonadal and somatotropic. Commonly it is a chronic treatment, requiring proper medical follow-up and therapeutic adjustment depending on clinical and hormonal control, except in ACTH deficits, where follow-up is fundamentally clinical.
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