Protocolo de estudio. Diseño del estudio ATLANTIS: evolución del síndrome de apneas-hipopneas durante el sueño en una cohorte clínica de niños. Aproximación a la historia natural de la enfermedad

Abstract

The ATLANTIS project is an observational, longitudinal and ambispective study that seeks to answer questions about the natural history of obstructive sleep apnoea syndrome (OSAS) over its course in a clinical child population. To this end, children between 0 and 14 referred to Burgoś Multidisciplinary Sleep Unit due to clinical suspicion of OSAS (presence of snoring and / or respiratory pauses) from 2000 to 2010 were included in the study. The study is carried out in 2phases, Phase I: All children referred with clinical suspicion of OSAS who underwent a clinical and sleep history, physical and otorhinolaryngological examination and sleep study (polysomnography or Respiratory Polygraphy) were analysed, identifying 2groups: OSAS and NO OSAS in turn<these are differentiated into 2subgroups: Surgical and Non-surgical treatment. In PHASE II: Prospective clinical and sleep history, physical and otorhinolaryngological examination and sleep study will be conducted prospectively to a random sample of each of the groups obtained from phase I. The objectives of the study are: 1) To describe and compare the clinical and polysomnographic characteristics of the child population with and without OSAS and identify the predictive variables of childhood OSAS; 2) Frequency of residual OSAS and its predictive factors; 3) Incidence of OSAS in children and their risk factors; 4) Frequency of remission of OSAS and its prognostic factors; 5) Frequency of recurrence of OSAS and its risk factors.