Abstract
IntroductionMinimal stimulation protocols based on clomiphene citrate are an effective alternative, easier, and inexpensive compared to conventional stimulation for IVF. The clinical and laboratory results obtained from 170 cycles of minimal stimulation are reported. Material and methodsA retrospective analysis of 170 cycles that were performed in this center from September 2013 to November 2014. ResultsOf the 170 analyzed cycles, 96.8% (158) reached oocyte retrieval, and 72.3% (123) had embryo transfer. A mean of 3.4 mature oocytes (metaphase II) were obtained, reporting a fertilization rate by intra-cytoplasmic sperm injection (ICSI) of 79%. A mean of 1.6 embryos were transferred, and the implantation rate was 30.3%, with a clinical pregnancy rate of39% per transfer. On analyzing cycles by age group, clinical pregnancy rate per cycle, oocyte retrieval and transfer was 49%, 55%, and 55%, respectively in patients under 35; 29.8%, 30.3%, and 45.9%, respectively, in patients between 35 and 40; and 12.9%, 15.1%, and 19.5%, respectively, in those cycles performed on patients older than 40. DiscussionMinimal stimulation is a real alternative for conventional protocols applied in IVF. Main advantages are less complexity, savings in medication, less invasive, and similar pregnancy rate when compared to conventional stimulation.
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