Abstract
BackgroundCardiovascular diseases (CVDs) remain the leading cause of premature mortality and burden of diseases in the world. The Inner Mongolia Autonomous Region is located in northern China, constitute 17.66% individuals with Mongolian, which have unique diet and lifestyles. Therefore, the Inner Mongolian Healthy Aging Study (IMAGINS) was designed to explore risk factors for chronic diseases and evaluate the effectiveness of health management on CVDs in population at high-risk.MethodsThe IMAGINS is an ongoing and prospective cohort study of men and women aged ≥35 years from Inner Mongolian Autonomous Region, northern China. This study performed in investigating risk factors for CVDs, screening and providing health management strategy for high-risk population of CVDs. The IMAGINS began in September 2015 and scheduled to recruiting and follow-up outcome until 2030. For general population, a long-term follow-up will be conducted every 5 years to collect the information above and data on clinical outcomes. For high-risk population, comprehensive health managements were performed and scheduled to follow-up annually. All IMAGINS participants are followed for incident CVDs and death.DiscussionThe IMAGINS is designed to increase understanding how cardiovascular-related risk factors contribute to the development of CVDs and the positive effect of health management strategy for high-risk CVD participants. Key features of this study include (i) a carefully characterized cohort between high risk of CVDs and non-high risk population; (ii) detailed measurement of CVDs risk factors and health management strategies for high risk population; (iii) long-term follow-up of CVDs and death. The IMAGINS represents a good research opportunity to investigate clinical and genetic factors in high-risk population, might providing basis for the prevention and control of non-communicable diseases.
Highlights
MethodsThe Inner Mongolian Healthy Aging Study (IMAGINS) is an ongoing and prospective cohort study of men and women aged ≥35 years from Inner Mongolian Autonomous Region, northern China
Cardiovascular diseases (CVDs) remain the leading cause of premature mortality and burden of diseases in the world
Recruitment and a long-term yearly follow-up will be performed until 2030, with the purposed of better understanding how cardiovascular-related risk factors contribute to the development of CVDs and the positive effect of health management strategy for high-risk CVD participants
Summary
Study design and participants The IMAGINS is an open and community-based longitudinal study in Inner Mongolian Autonomous Region, China. The CVDs high-risk was defined as the presence of one following criteria [34], as following, 1) history of MI or stroke, percutaneous coronary intervention, or coronary artery bypass grafting; 2) high blood pressure (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg), LDL-C ≥ 160 mg/dL (4.14 mmol/L), or HDL-C < 30 mg/dL (0.78 mmol/L); 3) based on WHO. The age, gender, income, marital status, highest education completed, smoking status, drinking status, BMI, waist circumference, blood pressure, fasting blood glucose, TC, TG, HDL-C, LDL-C, and history of diseases (hypertension, diabetes, and dyslipidemia) differed significantly between the high-risk group and nonrisk group (P < 0.05), whereas the differences of ethnicity was of no statistical significance (Table 3)
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