Protocol for Systematic Review of Efficacy and Safety of Ayurveda Interventions in Bronchial Asthma

Abstract

Introduction: A systematic review is planned to investigate the safety, efficacy, and effectiveness of Ayurvedic interventions in the management of Tamaka Shwasa/bronchial asthma through systematic analysis of published clinical researches. Materials and methods: A systematic review of the published clinical work for Ayurvedic interventions for Tamaka Shwasa/bronchial asthma will be conducted. Electronic searches, such as, EMBASE, MEDLINE, COCHRANE and AYUSH Research Portal, DHARA, Shodhganga Databases on dissertation works, conference proceedings, print journals, and reference list of articles, will be considered in the search strategy. All studies as per inclusion criteria including study design and participants will be analyzed by two investigators individually; in case of ambiguity, it will be discussed by a senior expert (investigator). The population (P in PICO) will include diagnosed cases of bronchial asthma/Tamaka Shwasa, where intervention (I) will be Ayurveda stand alone or as add-on with conventional therapy and (C) comparator will be Ayurveda and non- Ayurveda interventions or placebo. The primary outcome (O) will be improvement evident by a decrease in dyspnea, rhonchi, number of attacks, and classical symptoms of Tamaka Shwasa. Risk of bias assessment using Robin's tool will be used for non-randomized clinical trials, whereas CONSORT statement will be used for quality assessment of randomized clinical trials. Dissemination: This review is ongoing, and upon completion, the review will be published in a peer-reviewed journal. The review will be updated to inform and guide healthcare practice and policy. The results will be presented in terms of high risk, moderate or low/unclear risk in risk of bias assessment. Trial registration number: PROSPERO 2019 CRD42019123886.