Abstract
Abstract Gallbladder agenesis (GA) is a congenital anomaly of the biliary system, with characteristic absence of the gallbladder and cystic duct often with variable clinical presentation. Despite major advances in imaging technology many patients undergo unnecessary operative interventions during which the diagnosis is made. Very little is known on the management and outcomes in this patient population. Therefore, the main objective of this study protocol is to guide a comprehensive review of published cases of GA to evaluate and synthesize research findings on its presentation, management and clinical outcomes. This systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols guidelines. MEDLINE, via PubMed, EMBASE, SCOPUS and Google Scholar will be searched for articles on GA in humans (case report and case series) published before 1 October 2022 in English, French and Spanish. Two independent investigators will review each article, determine if it meets inclusion criteria, extract data and assess the study quality. A third investigator will arbitrate studies where there are conflicts between the first two investigators. Short and long-term outcomes will be compared between cases that underwent non-operative versus open versus laparoscopic surgery. Estimates will be made of odds ratios for dichotomous outcomes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Surgical Protocols and Research Methodologies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
