Abstract
BackgroundIrritable bowel syndrome (IBS) is a common chronic medical condition, in both children and adults. Despite the availability of effective (non)pharmacological treatments, symptoms persist in a significant amount of patients...
Highlights
Irritable bowel syndrome (IBS) is a common chronic medical condition, in both children and adults
►► It is suggested that irritable bowel syndrome (IBS) symptoms are generated through an effect of the microbiome on the intestinal barrier, enteroendocrine system, the immune system and the gut–brain axis
Secondary outcomes Secondary objectives include the proportion of patients with >50% reduction of their abdominal pain intensity and pain frequency compared with baseline at t=12 weeks after the first Faecal microbiota transplantation (FMT)
Summary
Irritable bowel syndrome (IBS) is a common chronic medical condition, in both children and adults. Discussion This randomised controlled trial will investigate the feasibility and effectiveness of repetitive FMTs in adolescents with refractory IBS. ►► This randomised controlled trial will investigate the feasibility and effectiveness of repetitive FMTs in adolescents with refractory IBS. To 11.9%, respectively.[1 2] Some studies report a peak prevalence in adolescents (12–19 years).[3] IBS impairs daily life, as patients report a decreased quality of life,[4 5] high work or school absence[6 7] and a higher risk to develop depressive and anxiety disorders compared with healthy controls.[7 8] healthcare costs are substantial.[9 10]. Either a pharmacological (tricyclic antidepressants, peppermint oil, linaclotide and lubiprostone) or non-pharmacological treatment (hypnotherapy and cognitive–behavioural therapy)
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