Abstract
CHRONIC allograft nephropathy (CAN) is the most common cause of late graft loss. CAN is indicated by a sustained decline in renal function usually in conjunction with proteinuria and hypertension. Unfortunately, once the clinical diagnosis of CAN is histologically confirmed, the degree of renal scarring is usually too advanced to begin effective therapy. Histologically, CAN is recognized by the presence of chronic tubulointerstitial damage, its severity is graded as mild, moderate, or severe according to the extension of interstitial fibrosis and tubular atrophy. Two types of CAN are distinguished: CAN (a) defined as tubulointerstitial chronic damage in the absence of transplant vasculopathy and CAN (b) defined as tubulointerstitial chronic damage associated with transplant vasculopathy.
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