Abstract
BackgroundRenal biopsy is often required to obtain information for diagnosis, management and prognosis of kidney disease that can be broadly classified into acute kidney injury (AKI) and chronic kidney disease (CKD). The most common conditions identified on renal biopsy are glomerulonephritis and tubulo-interstitial disorders. There is a paucity of information on management strategies and therapeutic outcomes in AKI and CKD patients. A renal biopsy registry will provide information on biopsy-proven kidney disorders to improve disease understanding and tracking, healthcare planning, patient care and outcomes.MethodsA registry of patients, that includes biopsy-proven kidney disease, was established through the collaboration of nephrologists from Queensland Hospital and Health Services and pathologists from Pathology Queensland services. The registry is in keeping with directions of the Advancing Kidney Care 2026 Collaborative, established in September 2018 as a Queensland Health initiative. Phase 1 of the registry entailed retrospective acquisition of data from all adult native kidney biopsies performed in Queensland, Australia, from 2002 to 2018. Data were also linked with the existing CKD.QLD patient registry. From 2019 onwards, phase 2 of the registry involves prospective collection of all incident consenting patients referred to Queensland public hospitals and having a renal biopsy. Annual reports on patient outcomes will be generated and disseminated.DiscussionEstablishment of the Queensland Renal Biopsy Registry (QRBR) aims to provide a profile of patients with biopsy-proven kidney disease that will lead to better understanding of clinico-pathological association and facilitate future research. It is expected to improve patient care and outcomes.
Highlights
Renal biopsy is often required to obtain information for diagnosis, management and prognosis of kidney disease that can be broadly classified into acute kidney injury (AKI) and chronic kidney disease (CKD)
AKI is estimated to occur in 16.9% of hospital episodes in Australia and New Zealand [1], and subsequent renal function decline is greater after AKI
The first national report on AKI in Australia has shown that AKI is a growing problem that disproportionally affects those residing in socioeconomically disadvantaged areas who have higher AKI hospitalisation and death rates [3]
Summary
Renal biopsy is often required to obtain information for diagnosis, management and prognosis of kidney disease that can be broadly classified into acute kidney injury (AKI) and chronic kidney disease (CKD). There is a paucity of information on management strategies and therapeutic outcomes in AKI and CKD patients. A renal biopsy registry will provide information on biopsy-proven kidney disorders to improve disease understanding and tracking, healthcare planning, patient care and outcomes. Kidney disease is an increasing healthcare problem both globally and in Australia. National renal biopsy registries provide useful information in biopsy-confirmed AKI. Spanish data from a renal registry study collected over a decade showed that 16.1% of the biopsies were diagnosed with AKI, with the prevalence order of biopsy-confirmed acute renal failure according to aetiology as vasculitis (23.3%), acute tubulointerstitial nephritis (11.3%) and crescentic glomerulonephritis (GN) (10.1%). This study highlighted that the prevalence of the different causes differed significantly according to age group [2]
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