Abstract

Systems chemistry has been a key component of origin of life research, invoking models of life’s inception based on evolving molecular networks. One such model is the graded autocatalysis replication domain (GARD) formalism embodied in a lipid world scenario, which offers rigorous computer simulation based on defined chemical kinetics equations. GARD suggests that the first pre-RNA life-like entities could have been homeostatically-growing assemblies of amphiphiles, undergoing compositional replication and mutations, as well as rudimentary selection and evolution. Recent progress in molecular dynamics has provided an experimental tool to study complex biological phenomena such as protein folding, ligand-receptor interactions, and micellar formation, growth, and fission. The detailed molecular definition of GARD and its inter-molecular catalytic interactions make it highly compatible with molecular dynamics analyses. We present a roadmap for simulating GARD’s kinetic and thermodynamic behavior using various molecular dynamics methodologies. We review different approaches for testing the validity of the GARD model by following micellar accretion and fission events and examining compositional changes over time. Near-future computational advances could provide empirical delineation for further system complexification, from simple compositional non-covalent assemblies towards more life-like protocellular entities with covalent chemistry that underlies metabolism and genetic encoding.

Highlights

  • Systems chemistry has been a key component of origin of life research, invoking models of life’s inception based on evolving molecular networks

  • The graded autocatalysis replication domain (GARD) model for life’s origin is based on the notion that the first rudiments of life were not individual molecular replicators, but rather self-reproducing multi-molecular systems, a concept pioneered by Oparin [1]

  • We have offered the term “systems protobiology” for the intermediate stages, including the possible early emergence of heterogeneous lipid assemblies, governed by GARD dynamics, and a capacity to gradually lead to other aspects of present-day life [8]

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Summary

Systems Chemistry in Life’s Origin

Alexander Oparin, life’s origin pioneer, wrote: “The process of evolution of organic compounds that led to the emergence of life can be divided into two major stages: chemical and prebiological. Life 2019, 9, 38 alludes to the idea that the transition from abiotic entities to such capable of natural selection was not centered on a single molecule, but rather constituted a multicomponent system In this respect, Oparin may be legitimately considered as a pioneer of systems chemistry and its relationship to the origin of life. An appreciable sector of life’s origins models adheres to the credo of systems chemistry, asserting that life likely began as a multi-molecular system capable of reproduction, selection, and evolution. Along these lines, early abiogenesis was followed by systems protobiology [8], a stage at which an assemblage of chemical compounds began to acquire life-like systems properties. The theoretical and experimental infrastructure for this view has been in existence for decades prior to the nominal advent of the Systems Chemistry concept [9,10,11,12,13,14], as reviewed [8,15,16]

Molecular Dynamics for Systems Chemistry
GARD: A Lipid-Based Systems Chemistry Model for Life’s Origin
Molecular Dynamics of Micelles and Mixed Micelles
Roadmap for GARD Evidence via Molecular Dynamics
Conclusions
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