Abstract
A tightly regulated protein quality control (PQC) system maintains a healthy balance between correctly folded and misfolded protein species. This PQC system work with the help of a complex network comprised of molecular chaperones and proteostasis. Any intruder, especially environmental pollutants, disrupt the PQC network and lead to PQCs disruption, thus generating damaged and infectious protein. These misfolded/unfolded proteins are linked to several diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and cataracts. Numerous studies on proteins misfolding and disruption of PQCs by environmental pollutants highlight the necessity of detailed knowledge. This review represents the PQCs network and environmental pollutants’ impact on the PQC network, especially through the protein clearance system.
Highlights
Eukaryotic cells have a well-organized, tightly regulated protein quality control (PQC)system
Error in the breakdown of aberrant polypeptides may result in protein aggregation which leads to pathological conditions such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), cataracts, and diabetes [10,11,12,13,14,15,16,17,18]
This review summarizes the essential PQC networks and the environmental pollutants which adversely affect the PQC
Summary
Eukaryotic cells have a well-organized, tightly regulated protein quality control (PQC). This quality control system includes the molecular chaperones, ubiquitin/proteasomedependent protein degradation, and autophagy machinery (target and uptake of non-native conformer in the spatial compartments) that consistently monitors and maintains the conformational state of cellular proteins. In eukaryotic cells, this surveillance is done by various structurally unrelated molecular chaperones [1,2,3,4,5,6]. Recent studies suggest the involvement of environmental toxicants such as pesticides, air pollutants, and heavy metals These environmental pollutants disrupt the PQCs network either by affecting molecular chaperones or proteasomal degradation machinery [21,22]. This review summarizes the essential PQC networks and the environmental pollutants which adversely affect the PQC system especially protein clearance machinery
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