Abstract
Several disciplines have recently emerged within biotechnology which for the first time enable biological systems to be studied on a scale commensurate with their inherent complexity. From the point of view of drug discovery, a critical role is fulfilled by proteomics, the systematic high-throughput separation and characterization of proteins within biological systems. Importantly, it is at the protein level that disease processes become manifest and at which most drugs act. Proteomics is consequently assuming a central place in modern drug development, with a wide spectrum of practical applications embracing diagnostics, target discovery, target validation, lead compound selection, investigation of drug modes of action, toxicology and clinical development.KeywordsTarget ValidationTarget DiscoveryHuman Breast Epithelial Cell LineZwitterionic DetergentRare ProteinThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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