Proteomics in Host-Protozoan Parasite Interactions and Development of Drug and Vaccine.

Awanish Kumar

doi:10.34172/apb.2021.024

Abstract

Protozoan parasites that cause disease in human (Leishmania, Plasmodium, Trypanosoma) reflect the balance of host defences and pathogen virulence at the time of invasion to the host. They have evolved a variety of strategies to subvert host defense functions. Proteomic technologies provide an opportunity to know the involvement of protein in the pathogenesis. With the help of proteomics tool, it is now possible to characterize host-protozoan parasite interactions. The outcome of this interaction is dependent on the gene/proteins expression of parasite that establish the infection to the host.

Highlights

Dear Editor, Current control measures of protozoan infection rely only on chemotherapy to improve the disease
Because of the accessibility of the relevant and advanced proteomics technology, the emphasis has been given to identifying novel target proteins that could serve as a potent drug target or vaccine candidate
Many laboratories across the globe are utilizing proteomics as rapidly emerging technology to elucidate the fundamental mechanism associated with the severity detection of disease, cancer development, drug development, and identification of disease conditions in patients.[7]

Summary

Introduction

Dear Editor, Current control measures of protozoan infection rely only on chemotherapy to improve the disease. The rapid expansion of our understanding in proteomics has directed to new understandings into their function and set the foundation for a more complete insight of how these parasites contribute to invasion and intracellular survival process in the host.[5] Immune responses to protozoan infection are highly multifaceted and it involves both humoral and cell-mediated responses to parasitic antigens array. The monocyte recruitment and antigen presentation at the site of infection appear to be perilous for the pathogenesis development of the protozoan parasite.

Results

Conclusion