Abstract
The aim of this study was to explore the mechanism of regulating the endocrine function of hyperplasia breast in rats with modified Mongolian medicine Sugmul-7 by proteomics, and provide experimental basis for its development and clinical application. Ninety female SD rats were randomly divided into normal group, model group, and modified Sugmul-7 low, medium, and high doses in a total of 5 groups. After the start of the experiment, each rat except the normal group was intraperitoneally injected with estradiol 25d and progesterone 6d at a standard dose of 0.3mg / kg for a total of 31 days. Four differential proteins were found through proteomic analysis, namely Ppp3cb, Cacybp, Gstz1Gstz1, and Nmd3 (and satisfying the standard conditions of 1.2 times to 0.8333 times) and found 5 related pathways. Mongolian medicine modified Sugmul-7 estradiol and progesterone-induced hyperplasia of the breast, Ppp3cb, Cacybp, Gstz1Gstz1, Nmd3 and other 4 differential proteins, through cGMP-PKG signal pathway, thyroid hormone signal pathway, estrogen signal pathway gastrointestinal signal related pathways, reproductive system related pathways, etc. regulate endocrine related pathways to treat the disease.
Highlights
Hyperplasia of mammary glands is a common breast disease in clinical practice
The pace of urban life will accelerate, social pressure will increase, and the impact of fertility will increase the incidence of breast hyperplasia year by year
Other pathogenesis has not been thoroughly studied, but it is preliminarily determined that it is caused by endocrine imbalance caused by emotions and certain external or internal causes
Summary
Hyperplasia of mammary glands is a common breast disease in clinical practice. This disease occurs in young and middle-aged women aged 25-45 years. According to the results of the investigation, [1, 2]. The pathogenesis of the disease is analyzed as: mental workers, nervousness, anxiety, dumbness, introverted personality, etc. The pace of urban life will accelerate, social pressure will increase, and the impact of fertility will increase the incidence of breast hyperplasia year by year. Other pathogenesis has not been thoroughly studied, but it is preliminarily determined that it is caused by endocrine imbalance caused by emotions and certain external or internal causes.
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