Abstract
Background Pain is defined as an unpleasant sensory and emotional experience, associated with a real or potential tissue damage. Chronic pain (CP) can arise from tissue injuries or inflammation (inflammatory pain), or from lesions of the peripheral or central nervous system (neuropathic pain). The purpose of this study was to search proteins potentially involved in the expression or mediation of pain utilizing proteomic techniques, in an animal model of CP obtained by the ligation of the sciatic nerve.
Highlights
Pain is defined as an unpleasant sensory and emotional experience, associated with a real or potential tissue damage
A prostaglandin with a pivotal role in central sensitization, involved in induction of hyperalgesia and cutaneous allodynia, was identified. This protein was detected in our previous study on medication-overuse headache (MOH) patients, where we found it significantly increased in urine of NSAIDs, mixture and triptans abusers, in respect to the healthy control group [2]
Authors’ details 1Department of Diagnostic Medicine, Clinic and Public Health, Proteomic Lab, University of Modena and Reggio Emilia, Modena, Italy
Summary
Pain is defined as an unpleasant sensory and emotional experience, associated with a real or potential tissue damage. Chronic pain (CP) can arise from tissue injuries or inflammation (inflammatory pain), or from lesions of the peripheral or central nervous system (neuropathic pain). The purpose of this study was to search proteins potentially involved in the expression or mediation of pain utilizing proteomic techniques, in an animal model of CP obtained by the ligation of the sciatic nerve
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