Abstract
Drug resistance of pathogen raises severe problems these decades since the antibiotic abuse. The need to explore the adaption mechanism of pathogens to antibiotic and develop new drugs is urgent. In this experiment, we explore the proteome of Salmonella enterica serovar Typhimurium under stress of berberine to study the adaption mechanism of S. Typhimurium to berberine. After proteomicanalysis, we found that energy metabolism-related proteins and flagellar proteinswere up-regulated and ribosome proteins were down-regulated under berberinepressure, revealing the potential mechanisms of growth inhibition of berberine to Salmonella. The possible inhiting mechanism include three parts: 1. The metabolismof S. Typhimurium was disturbed by Berberine; 2. Berberine has a negative effect on ribosomes of S. Typhimurium; 3. Berberine destroys the flagella of S. Typhimurium.
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