Abstract
Piperlongumine (PL) abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. Proteomic studies using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and LC-MS/MS analysis showed that PL inhibited collagen-induced aggregation in rabbit platelet cells induced by collagen. Addition of PL protected aggregation of rabbit platelet cells from collagen induction and mediated proteomic changes as 33 proteins decreased and 24 proteins increased. Coagulation factor and fibrinogen were down-regulated and they are involved in aggregation of the platelet cells. Antithrombogenic effect of PL was determined using mice with an i.v. injection of a mixture of collagen and epinephrine. Protection rate of PL on thrombogenic effect of the mixtures was up to 47.9% and it was 8.6% higher than that of aspirin. Taken together, these results strongly suggest that PL is considered as a potent medicine for treating unexpected platelet cell aggregation.
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