Abstract
The degradation activity of two bacteriophages UPMK_1 and UPMK_2 against methicillin-resistantStaphylococcus aureusphages were examined using gel zymography. The analysis was done using BLASTP to detect peptides catalytic domains. Many peptides that are related to several phage proteins were revealed. UPMK_1 and UPMK_2 custom sequence database were used for peptide identification. The biofilm-degrading proteins in the bacteriophage UPMK_2 revealed the same lytic activity towards polysaccharide intercellular adhesin-dependent and independent of Methicillin-resistantStaphylococcus aureus(MRSA) biofilm producers in comparison to UPMK_1, which had lytic activity restricted solely to its host. Both bacteriophage enzymes were involved in MRSA biofilm degradation during phage infection and they have promising enzybiotics properties against MRSA biofilm formation.
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