Abstract
Poor nutrition during early development may program adulthood diseases such as obesity. This study performed proteomic analysis of the retroperitoneal adipose tissue of adult male and female rats born from dams either fed ad libitum or restricted to 50% of ad lib intake during pregnancy. Tissue proteins were analyzed by 2‐D gel electrophoresis and Maldi‐Tof/Tof – MS. Mascot server was used to search Swiss‐Prot.Results: The restricted female progeny developed obesity and had 18 down‐regulated and 4 up‐regulated proteins. The restricted males did not develop obesity but still had 12 down‐regulated and 17 up‐regulated proteins. Although the majority of the differentially expressed proteins are related to metabolic processes and have catalytic activity , gender differences were evident. For example, cytoplasmic malate dehydrogenase was up‐regulated only in males while glyceraldehyde‐3‐phosphate dehydrogenase was up‐regulated only in females.ConclusionFemale but not male rats develop into obese adults when undernourished intrauterus. Important metabolic processes in adipose tissue are programmed by intrauterine undernutrition with different phenotypes between male and female adult rats. These may help explain the gender dimorphism in the obesogenic response.Funding: FAPESP, CNPq, Capes: Brazil
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