Abstract
Systems biology analysis of over 700 magnesium-dependent proteins in human proteome shown that these proteins affect (1) the embryonic development, (2) energy metabolism, (3) signal transduction processes from receptors, (4) neurological function, (5) support of connective tissue structure, (6) cardiovascular and (7) immunological roles. Magnesium deficiency during pregnancy will stimulate development of congential malformations (skeletal defects, rickets, hernia of the diaphragm, facial defects, craniosynostosis, structural disorders of the retina and vision, brachydactyly). Magnesium deficiency at an early age is associated with sudden death syndrome in preschool and adolescence leads to impaired function of skeletal muscles and myocardium. Magnesium deficiency is also characterized by mitochondrial disorders, hyperinsulinemia, disorders of the skin structure and its appendages, tumors and diseases associated with impaired energy metabolism (including hypoparathyroidism and anemia). Effects of magnesium deficiency in children significantly heavier on the background of lack of vitamin B6 (pyridoxine). The results of proteomic analysis enable to point out the relevant molecular and physiological mechanisms of synergy between magnesium and pyridoxine. Overall, the results of the analysis indicate a very extensive area for the correction of magnesium and pyridoxine deficiency for the prevention and treatment of a wide range of diseases, from the period of fetal development and early childhood through adolescence.
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