Abstract
Purpose: Osteoarthritis (OA) at the knees and hands may not share the same etiology. For example, pathogenesis of large joint OA like knee OA may be determined in large part by mechanopathology, while hand OA has been long considered the consequence of metabolic or systemic influences. Identifying shared aspects of disease across different joint sites may provide insights into relevant pathways that may be commonly targeted across different OA joint sites. We aimed to determine whether there are proteins associated with both knee and hand OA and whether these proteins are associated with disease incidence and prevalence.
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