Abstract
Proteomics is a field of study directed toward providing a comprehensive view of the characteristics and activity of every cellular protein. Rapid innovations in the core technologies required to characterize proteins on a global scale are poised to bring about a comprehensive understanding of how dynamic changes in protein expression, post-translational modification, and function affect complex signaling and regulatory networks. These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease.
Highlights
cellular interactions that can be perturbed in response to a multitude
how cellular proteomes are regulated in the nervous system in health and disease
characterize proteins on a global scale are poised to bring about a comprehensive understanding of how dynamic changes
Summary
Rapid innovations in the core technologies required to characterize proteins on a global scale are poised to bring about a comprehensive understanding of how dynamic changes in protein expression, post-translational modification, and function affect complex signaling and regulatory networks These advances have significant implications for understanding the multitude of pathways that govern behavior and cognition and the response of the nervous system to injury and disease. Recent advances in molecular biology, instrument technology, and bioinformatics are making it possible to simultaneously analyze the entire complement of genes expressed in a particular cell or tissue These advances have created unique opportunities in the field of medicine, where the results from gene expression studies are expected to help identify cellular alterations that are associated with disease etiology, progression, outcome, and response to therapy. The study of the genome, transcriptome, and proteome provides complementary insights into a host of biological processes and affords a greater understanding of the regulation of these processes
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