Abstract
Oocytes are crucial cells for mammalian reproduction, yet the molecular principles underlying oocyte development are only partially understood. Therefore, contemporary proteomic approaches have been used increasingly to provide new insights into oocyte quality and maturation in various species such as mouse, pig, and cow. Especially, animal studies have helped in elucidating the molecular status of oocytes during in vitro maturation and other procedures of assisted reproduction. The aim of this review is to summarize the literature on mammalian oocyte proteome and secretome research in the light of natural and assisted reproduction and on lessons to be learned for human oocytes, which have so far remained inaccessible for proteome analysis.
Highlights
The oocyte is one of the crucial cells in the live organisms, which enables the reproduction and continuation of the species
The aim of this review is to summarize the literature on mammalian oocyte proteome and secretome research in the light of natural and assisted reproduction and on lessons to be learned for human oocytes, which have so far remained inaccessible for proteome analysis
Several studies discussed in this paper showed that some epigenetics-related proteins such as nucleoplasmin 2 (NPM2), spindlin 1 (SPIN1), and protein-arginine deiminase type-6 (PADI6) were differently expressed between mature and immature animal oocytes indicating that these proteins are involved in the oocyte maturation process
Summary
The oocyte is one of the crucial cells in the live organisms, which enables the reproduction and continuation of the species. During oocyte growth and maturation a variety of maternally transcribed mRNAs accumulate, representing the maternal contribution to the oocyte and, the newly fertilized oocyte, zygote, and early embryo [7,8,9]. The majority of these mRNAs are stored in message ribonucleoprotein (mRNP) complexes and are only translated when needed at specific stages of maturation [10]. The aim of this review is to summarize the literature on animal oocyte proteome and secretome studies to elucidate what can be learned for human oocytes in the in vitro fertilization programme
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
