Proteome profiling for the identification of lung cancer signatures

Abstract

Evaluation of: Taguchi A, Politi K, Pitteri SJ et al. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 20(3), 289–299 (2011).Comprehensive and in-depth discovery of the disease proteome is an important issue in recent proteomics developments. Previous studies have shown a number of biomarkers discovered in various diseases, including lung cancer. Some of them are potentially useful in lung cancer diagnostics and prognostics. However, few of them can act as organ-specific biomarkers to extensively compare multiple cancer models. This article evaluates a recently published study employing comparative proteomics on multiple genetically engineered mouse models and sheds light on the usefulness and application of the discovered marker panel for human lung cancer diagnostics.