Proteome Analysis Suggests That Mitochondrial Dysfunction in Stressed Endothelial Cells Is Reversed by a Soy Extract and Isolated Isoflavones

Abstract

Apoptosis is a driving force in atherosclerosis development. A soy extract or a combination of the soy isoflavones genistein and daidzein inhibited apoptosis induced by oxidized LDL in endothelial cells. Proteome analysis revealed that the LDL-induced alterations of numerous proteins were reversed by the extract and the genistein/daidzein mixture but only three protein entities, all functionally linked to mitochondrial dysfunction, were regulated in common by both treatments.