Proteomanalyse des Myelins, der Isolierschicht der Nerven

Abstract

Rapid signal propagation along vertebrate axons is facilitated by their insulation with myelin, a plasma membrane specialization of glial cells. The recent application of proteomic approaches to biochemically purified myelin established that its protein composition is much more complex than previously thought. Bioinformatic integration of the myelin proteome with other systematic datasets such as mRNA abundance profiles of myelinating glial cells provides valuable resources for the molecular dissection of myelin biology and pathology.