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Abstract
The enzymatic mechanisms by which cercariae of Schistosoma mansoni invade mammalian skin have been investigated. Cercarial extracts prepared by sonication were assayed for activity against a variety of substrates including purified components of connective tissues. These extracts contain activity against gelatin, casein, Azocoll and elastin, but do not hydrolyze undenatured soluble or fibrous collagen. Cercarial extracts are very active against a chondromucoprotein complex from cartilage but do not hydrolyze the major mucopolysaccharide component of this complex. Sephadex G-150 chromatography of cercarial extracts revealed the existence of multiple peaks of proteolytic activity. It is suggested that carcarial proteases exert their main activity against the protein backbone of the protein-polysaccharide present in mammalian connective tissues.
Published Version
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